PHLOJEL® Ultra compounded with drugs rapidly penetrate the skin leaving no residue (except possibly when the drug content is high) or greasy feeling. After a few applications, and sometimes within a few minutes, the effects of the drug are felt by the patient. When high local tissue concentrations of drug are required, low blood levels are obtained [see graph below].
A human clinical study (10 healthy volunteers) demonstrated equal to superior transdermal delivery of diclofenac with PHLOJEL® Ultra when compared to a conventional Pluronic lecithin organogel (PLO).
Note that after 2% diclofenac sodium administration, plasma levels ranged from 5-15 ng/ml only and were approximately constant over an 8-h period.
When low blood levels of hormones are required, the blood is gradually infused with drug from lecithin depots located beneath the epidermis provided by the PHLOJEL® Ultra composition.